NEJM: Anti-interferon - autoneutralizing antibody with AIDS-like immunodeficiency

News

Time：2020-08-17Click：

Ifn - autoantibodies are associated with severe disseminated opportunistic infections, but their importance in infection prevalence needs further study. Recently, Sarah K. Browne, Ph.D., from the Clinical Infectious Disease Research Institute in Maryland, USA, and others have found that anti-interferon-gamma auto-neutralizing antibodies are associated with AiDS-like immunodeficiency in Asia. Their paper is published online in the authoritative international journal NEJM on August 23, 2012.

A total of 203 subjects from Taiwan and Thailand were enrolled and divided into five groups: group 1, 52 patients with diffuse, rapidly or chronically developing non-tubercular mycobacterial infections; Two groups, another opportunistic infection, with or without mycobacterium tuberculosis atypical infection of 45 patients; 3 groups, 9 patients with disseminated tuberculosis; There were 49 patients with pulmonary tuberculosis in 4 groups. Five groups and 48 healthy controls. In addition, the researchers recorded the clinical history of the subjects and obtained blood samples.

The results showed that CD4+ T-lymphocyte counts were similar in group 1 and group 2 as in group 4 and group 5, and none of them were infected with HIV. The cells were obtained and washed from group 1 and group 2 subjects to obtain complete cytokine production and response to cytokine stimulation. However, plasma obtained from these patients inhibited the activity of normal cellular interferon -. The researchers found that 81 per cent of patients in group 1 had detected high-potency anti-interferon - autoantibodies, compared with 96 per cent in group 2, 11 per cent in group 3 and 2 per cent in group 4 and 2 per cent in group 5. The researchers also analyzed 40 other anti-cytokine autoantibodies. They found that in one of the patients with Cryptococcal meningitis, autoantibodies were only responsive to granulocyte-macrophage colony stimulating factor, and no other anti-cytokine autoantibodies or infection-related genetic defects were found. In addition, the researchers found no family clusters.

The researchers concluded that anti-interferon - autoneutralizing antibodies were detected in 88 per cent of Asian adults with multiple opportunistic infections and were associated with hiv-like immunodeficiency in adults.